They emphasize that the development of myocomma originates from the segmentation period formed by sparse and loosely arranged collagen fibers. demonstrated the genesis of ECM during muscle fiber development using zebrafish as a module. Multilayer ECM is a common feature of vertebrates. Origination and structure of skeletal muscle ECM To provide a more comprehensive and systematic concept of the function of the extracellular matrix of skeletal muscle, we provide an overview over the current state of knowledge concerning the structure, composition, function, and application of ECM in skeletal muscle tissue. Although there have been numerous studies demonstrating the important role of ECM in skeletal muscle development, it is not very systematic. ECM has also been widely used in the fields of developmental biology, regenerative medicine, and bioengineering due to its important role in regulating cell physiological functions and its unique biological characteristics. With the further understanding of the mechanism of proliferation and differentiation of muscle cells, more and more attention has been paid to the important role of cell niche in development. Thus, it can be concluded that ECM plays a very important role in the maintenance of the physiological function of satellite cells and the development of skeletal muscle. confirmed that collagen I, a major ECM component, could promote the activation of focal adhesion kinase to regulate the nuclear translocation of NF-κB, and then enhanced the migration of myoblast. Researches indicated that the protein components in ECM participated in the myogenesis process of skeletal muscle progenitor cells, and the collagen secreted by satellite cells could maintain the quiescence of satellite cells. Study showed that the excessive accumulation of ECM in the cell microenvironment of aging muscle inhibited the myogenic differentiation ability of satellite cells. Moreover, a plurality of fasciculus form muscle mass, which are wrapped by the epimysium.ĮCM is involved in skeletal muscle development from embryonic stage to senescence. A number of muscle fibers form muscle bundles, which are wrapped by the perimysium. The innermost structure is called the basal membrane (basal lamina), which supports and wraps a single muscle fiber. The ECM of skeletal muscle tissue contains three layers. Extracellular matrix (ECM) presents in the muscle niche and is composed of proteins, polysaccharides, and RNA etc., which plays an important role in maintaining homeostasis and regulating the development of skeletal muscle. The microenvironment, in which muscle fibers and satellite cells inhabit, also known as niche, has important effects on the growth of muscle fibers and myogenic differentiation of satellite cells. Muscle fibers and muscle progenitor cells (satellite cells) reside in the skeletal muscle microenvironment. Skeletal muscle is an important organ of locomotion and metabolism in the body, which plays a very important role in maintaining the exercise balance, glucose metabolism, and energy metabolism of the body.